I can successfully access amazon.com with several browsers on my macOS 10.12.6, LS 4.02. As of today, when I try to access smile.amazon.com on several browsers I get the error "The site cannot be reached. smile.amazon.com unexpectedly closed the connection."
If I turn off LS filtering I can access that site fine. I've looked through the rules I have and can't find any likely candidate for the problem.
FYI smile.amazon donates a REALLY small amount of your purchase to a charity of your choice.